Boy George joined the cast of Taboo at the same time as Lyn Paul, making his West End début as Leigh Bowery on 6th May 2002.
"The cast album for Taboo is well on it's way to being finished, but has been put on hold while the technical side of the team, Kevan Frost, takes a two-week breather in Canada. I let him go on the condition that we finished the B-side of Lyn Paul's song from the show. I'm hoping that Talk Amongst Yourselves will be the first single from the Taboo cast album. Anyone who saw and heard Lyn sing at the Albert Hall will know why. We recorded a really stripped down version of Joni Mitchell's Case Of You, from the album Blue. I can't believe Lyn hasn't recorded in 18 years and that she still has that powerful voice."
Julian Clary joined the London cast of Taboo on 9th September 2002, taking over the role of Leigh Bowery from Boy George.
Luke Evans played Billy in the London production of Taboo. In October 2007, in an interview with What's On Stage, Luke recalled the day he discovered that Lyn Paul was joining the cast: "When I was in 'Taboo', the woman who played my mum originally was Gemma Craven. One day they told us that Lyn Paul was taking over from her. I was a huge fan of Lyn Paul in 'Blood Brothers' when I was 17 or 18. When my family came to London, I always used to take them to see 'Blood Brothers' because I loved Lyn Paul in it. She was just amazing in the part of Mrs. Johnstone. I used to wait outside the stage door to get her autograph and tell her I thought she was fantastic! So I couldn't believe it... when you have respect for a fellow actor and then you get to work with them, it's really nice."
Drew Jaymson was in the original London cast of Taboo. He played the part of Steve Strange.
Gail Mackinnon, another member of the original cast, played the part of Big Sue until 16th March 2003.
Euan Morton was a member of the original London cast, playing the part of George O'Dowd (Boy George) to great critical acclaim. Euan reprised his role in the short-lived New York production of Taboo, which played at the Plymouth Theatre on Broadway from 28th October 2003 to 8th February 2004.